Reproductive factors and Parkinson's disease: A multicenter case–control study
Identifieur interne : 001447 ( Main/Corpus ); précédent : 001446; suivant : 001448Reproductive factors and Parkinson's disease: A multicenter case–control study
Auteurs : Alessandra Nicoletti ; Giuseppe Nicoletti ; Gennarina Arabia ; Grazia Annesi ; Michele De Mari ; Paolo Lamberti ; Lucia Grasso ; Roberto Marconi ; Antonio Epifanio ; Letterio Morgante ; Autilia Cozzolino ; Paolo Barone ; Aldo Quattrone ; Mario ZappiaSource :
- Movement Disorders [ 0885-3185 ] ; 2011-12.
English descriptors
Abstract
Background:: The objective of this study was to evaluate the possible association between endogenous and exogenous estrogens and Parkinson's disease (PD). Methods:: The FRAGAMP study is a large Italian multicenter case–control study. PD was diagnosed according to Gelb's criteria. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Adjusted ORs and 95% CIs were estimated using multivariate analysis (logistic regression). Results:: Two hundred PD women (mean age, 68.0 ± 9.5 years) and 299 control women (mean age, 61.8 ± 9.9 years) were enrolled in the study. Age at menarche, age at menopause, fertile life duration, cumulative duration of pregnancies, hormone replacement therapy, and surgical menopause were not significantly associated with PD. Multivariate analysis showed a significant positive association between use of oral contraceptives and PD, with an adjusted OR of 3.27 (95% CI, 1.24–8.59; P = .01). Conclusions:: Our data suggest that oral contraceptives could increase the risk of PD. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23951
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reproductive factors and Parkinson's disease: A multicenter case–control study</title><author><name sortKey="Nicoletti, Alessandra" sort="Nicoletti, Alessandra" uniqKey="Nicoletti A" first="Alessandra" last="Nicoletti">Alessandra Nicoletti</name><affiliation><mods:affiliation>Dipartimento “Ingrassia” Sezione di Neuroscienze, Università di Catania, Catania, Italy</mods:affiliation></affiliation></author><author><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name><affiliation><mods:affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name><affiliation><mods:affiliation>Institute of Neurology, University “Magna Græcia” of Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><mods:affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="De Mari, Michele" sort="De Mari, Michele" uniqKey="De Mari M" first="Michele" last="De Mari">Michele De Mari</name><affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche e Psichiatriche, Università di Bari, Bari, Italy</mods:affiliation></affiliation></author><author><name sortKey="Lamberti, Paolo" sort="Lamberti, Paolo" uniqKey="Lamberti P" first="Paolo" last="Lamberti">Paolo Lamberti</name><affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche e Psichiatriche, Università di Bari, Bari, Italy</mods:affiliation></affiliation></author><author><name sortKey="Grasso, Lucia" sort="Grasso, Lucia" uniqKey="Grasso L" first="Lucia" last="Grasso">Lucia Grasso</name><affiliation><mods:affiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</mods:affiliation></affiliation></author><author><name sortKey="Marconi, Roberto" sort="Marconi, Roberto" uniqKey="Marconi R" first="Roberto" last="Marconi">Roberto Marconi</name><affiliation><mods:affiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</mods:affiliation></affiliation></author><author><name sortKey="Epifanio, Antonio" sort="Epifanio, Antonio" uniqKey="Epifanio A" first="Antonio" last="Epifanio">Antonio Epifanio</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</mods:affiliation></affiliation></author><author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</mods:affiliation></affiliation></author><author><name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name><affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università Federico II, e IDC Hermitage, Napoli, Italy</mods:affiliation></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università Federico II, e IDC Hermitage, Napoli, Italy</mods:affiliation></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><mods:affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Neuroimaging Research Unit, National Research Council, Campus di Germaneto, Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name><affiliation><mods:affiliation>Dipartimento “Ingrassia” Sezione di Neuroscienze, Università di Catania, Catania, Italy</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:087172D15D9F5DA353F82ABC9488FE641F1D6844</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23951</idno><idno type="url">https://api.istex.fr/document/087172D15D9F5DA353F82ABC9488FE641F1D6844/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001447</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Reproductive factors and Parkinson's disease: A multicenter case–control study</title><author><name sortKey="Nicoletti, Alessandra" sort="Nicoletti, Alessandra" uniqKey="Nicoletti A" first="Alessandra" last="Nicoletti">Alessandra Nicoletti</name><affiliation><mods:affiliation>Dipartimento “Ingrassia” Sezione di Neuroscienze, Università di Catania, Catania, Italy</mods:affiliation></affiliation></author><author><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name><affiliation><mods:affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name><affiliation><mods:affiliation>Institute of Neurology, University “Magna Græcia” of Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><mods:affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="De Mari, Michele" sort="De Mari, Michele" uniqKey="De Mari M" first="Michele" last="De Mari">Michele De Mari</name><affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche e Psichiatriche, Università di Bari, Bari, Italy</mods:affiliation></affiliation></author><author><name sortKey="Lamberti, Paolo" sort="Lamberti, Paolo" uniqKey="Lamberti P" first="Paolo" last="Lamberti">Paolo Lamberti</name><affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche e Psichiatriche, Università di Bari, Bari, Italy</mods:affiliation></affiliation></author><author><name sortKey="Grasso, Lucia" sort="Grasso, Lucia" uniqKey="Grasso L" first="Lucia" last="Grasso">Lucia Grasso</name><affiliation><mods:affiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</mods:affiliation></affiliation></author><author><name sortKey="Marconi, Roberto" sort="Marconi, Roberto" uniqKey="Marconi R" first="Roberto" last="Marconi">Roberto Marconi</name><affiliation><mods:affiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</mods:affiliation></affiliation></author><author><name sortKey="Epifanio, Antonio" sort="Epifanio, Antonio" uniqKey="Epifanio A" first="Antonio" last="Epifanio">Antonio Epifanio</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</mods:affiliation></affiliation></author><author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</mods:affiliation></affiliation></author><author><name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name><affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università Federico II, e IDC Hermitage, Napoli, Italy</mods:affiliation></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università Federico II, e IDC Hermitage, Napoli, Italy</mods:affiliation></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><mods:affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Neuroimaging Research Unit, National Research Council, Campus di Germaneto, Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name><affiliation><mods:affiliation>Dipartimento “Ingrassia” Sezione di Neuroscienze, Università di Catania, Catania, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-12">2011-12</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2563">2563</biblScope><biblScope unit="page" to="2566">2566</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">087172D15D9F5DA353F82ABC9488FE641F1D6844</idno><idno type="DOI">10.1002/mds.23951</idno><idno type="ArticleID">MDS23951</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>case‐control study</term><term>reproductive factors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: The objective of this study was to evaluate the possible association between endogenous and exogenous estrogens and Parkinson's disease (PD). Methods:: The FRAGAMP study is a large Italian multicenter case–control study. PD was diagnosed according to Gelb's criteria. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Adjusted ORs and 95% CIs were estimated using multivariate analysis (logistic regression). Results:: Two hundred PD women (mean age, 68.0 ± 9.5 years) and 299 control women (mean age, 61.8 ± 9.9 years) were enrolled in the study. Age at menarche, age at menopause, fertile life duration, cumulative duration of pregnancies, hormone replacement therapy, and surgical menopause were not significantly associated with PD. Multivariate analysis showed a significant positive association between use of oral contraceptives and PD, with an adjusted OR of 3.27 (95% CI, 1.24–8.59; P = .01). Conclusions:: Our data suggest that oral contraceptives could increase the risk of PD. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Alessandra Nicoletti MD, MSc</name><affiliations><json:string>Dipartimento “Ingrassia” Sezione di Neuroscienze, Università di Catania, Catania, Italy</json:string></affiliations></json:item><json:item><name>Giuseppe Nicoletti MD</name><affiliations><json:string>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</json:string></affiliations></json:item><json:item><name>Gennarina Arabia MD, MSc</name><affiliations><json:string>Institute of Neurology, University “Magna Græcia” of Catanzaro, Italy</json:string></affiliations></json:item><json:item><name>Grazia Annesi PhD</name><affiliations><json:string>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</json:string></affiliations></json:item><json:item><name>Michele De Mari MD</name><affiliations><json:string>Dipartimento di Scienze Neurologiche e Psichiatriche, Università di Bari, Bari, Italy</json:string></affiliations></json:item><json:item><name>Paolo Lamberti MD</name><affiliations><json:string>Dipartimento di Scienze Neurologiche e Psichiatriche, Università di Bari, Bari, Italy</json:string></affiliations></json:item><json:item><name>Lucia Grasso LLD</name><affiliations><json:string>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</json:string></affiliations></json:item><json:item><name>Roberto Marconi MD</name><affiliations><json:string>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</json:string></affiliations></json:item><json:item><name>Antonio Epifanio MD</name><affiliations><json:string>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</json:string></affiliations></json:item><json:item><name>Letterio Morgante MD</name><affiliations><json:string>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</json:string></affiliations></json:item><json:item><name>Autilia Cozzolino MD</name><affiliations><json:string>Dipartimento di Scienze Neurologiche, Università Federico II, e IDC Hermitage, Napoli, Italy</json:string></affiliations></json:item><json:item><name>Paolo Barone MD</name><affiliations><json:string>Dipartimento di Scienze Neurologiche, Università Federico II, e IDC Hermitage, Napoli, Italy</json:string></affiliations></json:item><json:item><name>Aldo Quattrone MD</name><affiliations><json:string>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</json:string><json:string>Neuroimaging Research Unit, National Research Council, Campus di Germaneto, Catanzaro, Italy</json:string></affiliations></json:item><json:item><name>Mario Zappia MD</name><affiliations><json:string>Dipartimento “Ingrassia” Sezione di Neuroscienze, Università di Catania, Catania, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>reproductive factors</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>case‐control study</value></json:item></subject><articleId><json:string>MDS23951</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background:: The objective of this study was to evaluate the possible association between endogenous and exogenous estrogens and Parkinson's disease (PD). Methods:: The FRAGAMP study is a large Italian multicenter case–control study. PD was diagnosed according to Gelb's criteria. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Adjusted ORs and 95% CIs were estimated using multivariate analysis (logistic regression). Results:: Two hundred PD women (mean age, 68.0 ± 9.5 years) and 299 control women (mean age, 61.8 ± 9.9 years) were enrolled in the study. Age at menarche, age at menopause, fertile life duration, cumulative duration of pregnancies, hormone replacement therapy, and surgical menopause were not significantly associated with PD. Multivariate analysis showed a significant positive association between use of oral contraceptives and PD, with an adjusted OR of 3.27 (95% CI, 1.24–8.59; P = .01). Conclusions:: Our data suggest that oral contraceptives could increase the risk of PD. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>6.896</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>1089</abstractCharCount><pdfWordCount>12490</pdfWordCount><pdfCharCount>83283</pdfCharCount><pdfPageCount>20</pdfPageCount><abstractWordCount>158</abstractWordCount></qualityIndicators><title>Reproductive factors and Parkinson's disease: A multicenter case–control study</title><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>4</total><last>2566</last><first>2563</first></pages><issn><json:string>0885-3185</json:string></issn><issue>14</issue><subject><json:item><value>Brief 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type="first">Alessandra</forename><surname>Nicoletti</surname></persName><roleName type="degree">MD, MSc</roleName><affiliation>Dipartimento “Ingrassia” Sezione di Neuroscienze, Università di Catania, Catania, Italy</affiliation></author><author><persName><forename type="first">Giuseppe</forename><surname>Nicoletti</surname></persName><roleName type="degree">MD</roleName><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation></author><author><persName><forename type="first">Gennarina</forename><surname>Arabia</surname></persName><roleName type="degree">MD, MSc</roleName><affiliation>Institute of Neurology, University “Magna Græcia” of Catanzaro, Italy</affiliation></author><author><persName><forename type="first">Grazia</forename><surname>Annesi</surname></persName><roleName type="degree">PhD</roleName><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation></author><author><persName><forename type="first">Michele</forename><surname>De Mari</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Scienze Neurologiche e Psichiatriche, Università di Bari, Bari, Italy</affiliation></author><author><persName><forename type="first">Paolo</forename><surname>Lamberti</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Scienze Neurologiche e Psichiatriche, Università di Bari, Bari, Italy</affiliation></author><author><persName><forename type="first">Lucia</forename><surname>Grasso</surname></persName><roleName type="degree">LLD</roleName><affiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</affiliation></author><author><persName><forename type="first">Roberto</forename><surname>Marconi</surname></persName><roleName type="degree">MD</roleName><affiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</affiliation></author><author><persName><forename type="first">Antonio</forename><surname>Epifanio</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</affiliation></author><author><persName><forename type="first">Letterio</forename><surname>Morgante</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</affiliation></author><author><persName><forename type="first">Autilia</forename><surname>Cozzolino</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Scienze Neurologiche, Università Federico II, e IDC Hermitage, Napoli, Italy</affiliation></author><author><persName><forename type="first">Paolo</forename><surname>Barone</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Scienze Neurologiche, Università Federico II, e IDC Hermitage, Napoli, Italy</affiliation></author><author><persName><forename type="first">Aldo</forename><surname>Quattrone</surname></persName><roleName type="degree">MD</roleName><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation><affiliation>Neuroimaging Research Unit, National Research Council, Campus di Germaneto, Catanzaro, Italy</affiliation></author><author><persName><forename type="first">Mario</forename><surname>Zappia</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Department “Ingrassia,” Section of Neurosciences, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy</p></note><affiliation>Dipartimento “Ingrassia” Sezione di Neuroscienze, Università di Catania, Catania, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-12"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2563">2563</biblScope><biblScope unit="page" to="2566">2566</biblScope></imprint></monogr><idno type="istex">087172D15D9F5DA353F82ABC9488FE641F1D6844</idno><idno type="DOI">10.1002/mds.23951</idno><idno type="ArticleID">MDS23951</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background:: The objective of this study was to evaluate the possible association between endogenous and exogenous estrogens and Parkinson's disease (PD). Methods:: The FRAGAMP study is a large Italian multicenter case–control study. PD was diagnosed according to Gelb's criteria. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Adjusted ORs and 95% CIs were estimated using multivariate analysis (logistic regression). Results:: Two hundred PD women (mean age, 68.0 ± 9.5 years) and 299 control women (mean age, 61.8 ± 9.9 years) were enrolled in the study. Age at menarche, age at menopause, fertile life duration, cumulative duration of pregnancies, hormone replacement therapy, and surgical menopause were not significantly associated with PD. Multivariate analysis showed a significant positive association between use of oral contraceptives and PD, with an adjusted OR of 3.27 (95% CI, 1.24–8.59; P = .01). Conclusions:: Our data suggest that oral contraceptives could increase the risk of PD. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>reproductive factors</term></item><item><term>case‐control study</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-12-10">Received</change><change when="2011-08-11">Registration</change><change when="2011-12">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/087172D15D9F5DA353F82ABC9488FE641F1D6844/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="140"><doi origin="wiley" registered="yes">10.1002/mds.v26.14</doi><numberingGroup><numbering type="journalVolume" number="26">26</numbering><numbering type="journalIssue">14</numbering></numberingGroup><coverDate startDate="2011-12">December 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="260" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23951</doi><idGroup><id type="unit" value="MDS23951"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2011 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2010-12-10"></event><event type="manuscriptRevised" date="2011-06-27"></event><event type="manuscriptAccepted" date="2011-08-11"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.0.1 mode:FullText" date="2012-01-13"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-09-28"></event><event type="publishedOnlineFinalForm" date="2011-12-14"></event><event type="firstOnline" date="2011-09-28"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">2563</numbering><numbering type="pageLast">2566</numbering></numberingGroup><correspondenceTo>Department “Ingrassia,” Section of Neurosciences, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23951.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="23"></count><count type="wordTotal" number="3996"></count></countGroup><titleGroup><title type="main" xml:lang="en">Reproductive factors and Parkinson's disease: A multicenter case–control study<link href="#fn2"></link><link href="#fn3"></link></title><title type="short" xml:lang="en">Reproductive Factors and Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Alessandra</givenNames><familyName>Nicoletti</familyName><degrees>MD, MSc</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Giuseppe</givenNames><familyName>Nicoletti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Gennarina</givenNames><familyName>Arabia</familyName><degrees>MD, MSc</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Grazia</givenNames><familyName>Annesi</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Michele</givenNames><familyName>De Mari</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Paolo</givenNames><familyName>Lamberti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Lucia</givenNames><familyName>Grasso</familyName><degrees>LLD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Roberto</givenNames><familyName>Marconi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Antonio</givenNames><familyName>Epifanio</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Letterio</givenNames><familyName>Morgante</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Autilia</givenNames><familyName>Cozzolino</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Paolo</givenNames><familyName>Barone</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af2 #af8"><personName><givenNames>Aldo</givenNames><familyName>Quattrone</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Mario</givenNames><familyName>Zappia</familyName><degrees>MD</degrees></personName><contactDetails><email>m.zappia@unict.it</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento “Ingrassia” Sezione di Neuroscienze, Università di Catania, Catania, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>Institute of Neurology, University “Magna Græcia” of Catanzaro, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Scienze Neurologiche e Psichiatriche, Università di Bari, Bari, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="IT" type="organization"><unparsedAffiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Scienze Neurologiche, Università Federico II, e IDC Hermitage, Napoli, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="IT" type="organization"><unparsedAffiliation>Neuroimaging Research Unit, National Research Council, Campus di Germaneto, Catanzaro, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">reproductive factors</keyword><keyword xml:id="kwd3">case‐control study</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main"><b>Background:</b></title><p>The objective of this study was to evaluate the possible association between endogenous and exogenous estrogens and Parkinson's disease (PD).</p></section><section xml:id="abs1-2"><title type="main"><b>Methods:</b></title><p>The FRAGAMP study is a large Italian multicenter case–control study. PD was diagnosed according to Gelb's criteria. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Adjusted ORs and 95% CIs were estimated using multivariate analysis (logistic regression).</p></section><section xml:id="abs1-3"><title type="main"><b>Results:</b></title><p>Two hundred PD women (mean age, 68.0 ± 9.5 years) and 299 control women (mean age, 61.8 ± 9.9 years) were enrolled in the study. Age at menarche, age at menopause, fertile life duration, cumulative duration of pregnancies, hormone replacement therapy, and surgical menopause were not significantly associated with PD. Multivariate analysis showed a significant positive association between use of oral contraceptives and PD, with an adjusted OR of 3.27 (95% CI, 1.24–8.59; <i>P</i> = .01).</p></section><section xml:id="abs1-4"><title type="main"><b>Conclusions:</b></title><p>Our data suggest that oral contraceptives could increase the risk of PD. © 2011 Movement Disorder Society</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p><b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report.</p></note><note xml:id="fn3"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Reproductive factors and Parkinson's disease: A multicenter case–control study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Reproductive Factors and Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Reproductive factors and Parkinson's disease: A multicenter case–control study</title></titleInfo><name type="personal"><namePart type="given">Alessandra</namePart><namePart type="family">Nicoletti</namePart><namePart type="termsOfAddress">MD, MSc</namePart><affiliation>Dipartimento “Ingrassia” Sezione di Neuroscienze, Università di Catania, Catania, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giuseppe</namePart><namePart type="family">Nicoletti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gennarina</namePart><namePart type="family">Arabia</namePart><namePart type="termsOfAddress">MD, MSc</namePart><affiliation>Institute of Neurology, University “Magna Græcia” of Catanzaro, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Grazia</namePart><namePart type="family">Annesi</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michele</namePart><namePart type="family">De Mari</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Scienze Neurologiche e Psichiatriche, Università di Bari, Bari, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paolo</namePart><namePart type="family">Lamberti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Scienze Neurologiche e Psichiatriche, Università di Bari, Bari, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lucia</namePart><namePart type="family">Grasso</namePart><namePart type="termsOfAddress">LLD</namePart><affiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">Marconi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio</namePart><namePart type="family">Epifanio</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Letterio</namePart><namePart type="family">Morgante</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Autilia</namePart><namePart type="family">Cozzolino</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Scienze Neurologiche, Università Federico II, e IDC Hermitage, Napoli, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paolo</namePart><namePart type="family">Barone</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Scienze Neurologiche, Università Federico II, e IDC Hermitage, Napoli, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aldo</namePart><namePart type="family">Quattrone</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation><affiliation>Neuroimaging Research Unit, National Research Council, Campus di Germaneto, Catanzaro, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mario</namePart><namePart type="family">Zappia</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento “Ingrassia” Sezione di Neuroscienze, Università di Catania, Catania, Italy</affiliation><description>Correspondence: Department “Ingrassia,” Section of Neurosciences, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-12</dateIssued><dateCaptured encoding="w3cdtf">2010-12-10</dateCaptured><dateValid encoding="w3cdtf">2011-08-11</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">2</extent><extent unit="references">23</extent><extent unit="words">3996</extent></physicalDescription><abstract lang="en">Background:: The objective of this study was to evaluate the possible association between endogenous and exogenous estrogens and Parkinson's disease (PD). Methods:: The FRAGAMP study is a large Italian multicenter case–control study. PD was diagnosed according to Gelb's criteria. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Adjusted ORs and 95% CIs were estimated using multivariate analysis (logistic regression). Results:: Two hundred PD women (mean age, 68.0 ± 9.5 years) and 299 control women (mean age, 61.8 ± 9.9 years) were enrolled in the study. Age at menarche, age at menopause, fertile life duration, cumulative duration of pregnancies, hormone replacement therapy, and surgical menopause were not significantly associated with PD. Multivariate analysis showed a significant positive association between use of oral contraceptives and PD, with an adjusted OR of 3.27 (95% CI, 1.24–8.59; P = .01). Conclusions:: Our data suggest that oral contraceptives could increase the risk of PD. © 2011 Movement Disorder Society</abstract><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>reproductive factors</topic><topic>case‐control study</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>14</number></detail><extent unit="pages"><start>2563</start><end>2566</end><total>4</total></extent></part></relatedItem><identifier type="istex">087172D15D9F5DA353F82ABC9488FE641F1D6844</identifier><identifier type="DOI">10.1002/mds.23951</identifier><identifier type="ArticleID">MDS23951</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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